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April and May are two young girls running away from the police. They have murdered, beheaded and eaten parts of their victims.

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At a bus stop they meet Francesca, an eighteen year old who is collaborating in a veterinary office, and Claudio, a university student. The two begin to walk together and talk about many things.

A hotheaded Alaskan customs agent (Sean Patrick Flannery) unwillingly teams up with a coldhearted but beautiful Soviet agent (Ursula Karven) to capture a rogue Russian general (Arnold Vosloo), selling a shipment of deadly nerve gas. Tensions and passions spin out of control after two agents are left for dead and they must combine forces to survive. They have one chance laft to take out the General and destroy the "Apocalypse in a can" nerve agent, both speeding toward freedom on a runaway mountain train. Unexpected twists and terrifying turns along the way put everyone on a collision course for explosive action, pulse-pounding thrill and a devastating betrayal of trust.

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